Eculizumab

BreastfeedingPediatric
CLINICALLY IMPORTANT, POTENTIALLY HAZARDOUS INTERACTIONS WITH:

None known

PREGNANCY CATEGORY: C

Under investigation for treating COVID-19

See adverse reactions attributed to class:

Covid-19 putative drug

SERIOUS MENINGOCOCCAL INFECTIONS

See full prescribing information for complete boxed warning.

Bruise / bruising / contusion / ecchymosis (ecchymoses) 

(2021): Zhou S+, J Pediatr Hematol Oncol Apr, Online ahead of print [REVIEW]

Dermatitis 

(2015): Licht C+, Kidney Int 87(5), 10616%

Erythema 

(2015): Licht C+, Kidney Int 87(5), 10616%

Hematoma 

(2013): Hillmen P+, Br J Haematol 162(1), 6215%

Herpes zoster 

(2015): Licht C+, Kidney Int 87(5), 10616%

Impetigo 

(2015): Licht C+, Kidney Int 87(5), 10616%

Peripheral edema (see also edema) 

(2013): Hillmen P+, Br J Haematol 162(1), 6210%

(2013): Rathbone J+, BMJ Open 3(11), Epub [REVIEW]11%

Photosensitivity 

(2010): Balagula Y+, Am J Hematol 85 (5), 392

Pruritus (itching) 

(2015): Licht C+, Kidney Int 87(5), 10615%

(2013): Hillmen P+, Br J Haematol 162(1), 6210%

Rash 

(2013): Hillmen P+, Br J Haematol 162(1), 6210%

Septic–toxic shock 

(2012): Gleesing J+, Pediatr Infect Dis J 31(5)

Alopecia / hair loss 

(2015): Licht C+, Kidney Int 87(5), 10615%

Epistaxis (nosebleed) 

(2013): Hillmen P+, Br J Haematol 162(1), 6211%

Nasal congestion 

(2015): Licht C+, Kidney Int 87(5), 10615%

(2013): Rathbone J+, BMJ Open 3(11), Epub [REVIEW]21%

Oropharyngeal pain 

(2013): Hillmen P+, Br J Haematol 162(1), 6222%

Rhinorrhea 

(2015): Licht C+, Kidney Int 87(5), 10615%

Chest pain 

(2015): Licht C+, Kidney Int 87(5), 10615%

Extravasation 

(2015): Licht C+, Kidney Int 87(5), 10615%

Hypertension 

(2015): Licht C+, Kidney Int 87(5), 10616%

(2013): Rathbone J+, BMJ Open 3(11), Epub [REVIEW]35%

Hypotension 

(2015): Licht C+, Kidney Int 87(5), 10615%

Tachycardia 

(2013): Rathbone J+, BMJ Open 3(11), Epub [REVIEW]21%

Fever (pyrexia) 

(2021): Zhou S+, J Pediatr Hematol Oncol Apr, Online ahead of print [REVIEW]

(2015): Licht C+, Kidney Int 87(5), 10616%

(2013): Hillmen P+, Br J Haematol 162(1), 6221%

(2013): Rathbone J+, BMJ Open 3(11), Epub [REVIEW]11–47%

Headache 44%

(2021): Murai H+, Ther Adv Neurol Disord Mar, eCollection (3 cases)

(2021): Zhou S+, J Pediatr Hematol Oncol Apr, Online ahead of print [REVIEW]

(2018): Kulasekararaj AG+, Blood Dec, Epub ahead of print17%

(2017): Howard JF Jr+, Lancet Neurol 16(12), 97616%

(2015): Licht C+, Kidney Int 87(5), 106115%

(2013): Hardinger KL+, World J Transplant 3(4), 68 [REVIEW]

(2013): Hillmen P+, Br J Haematol 162(1), 6255%

(2013): Rathbone J+, BMJ Open 3(11), Epub [REVIEW]30%

(2008): Davis J, Am J Health Syst Pharm 65 (17), 1609

Insomnia 

(2013): Hillmen P+, Br J Haematol 162(1), 6212%

(2013): Rathbone J+, BMJ Open 3(11), Epub [REVIEW]14%

Intracranial hemorrhage 

(2018): Misawa S+, Lancet Neurol Apr, Epub ahead of print

Meningococcal infection 

(2015): Cullinan N+, Pediatrics 135(6), e1506

(2013): Pittock SJ+, Lancet Neurol 12(6), 554 (1 case)

(2013): Rey-Mugica Mde L+, Enferm Infecc Microbiol Clin 31(1), 62

(2013): Struijk GH+, Am J Transplant 13(3), 819

Tremor 

(2015): Licht C+, Kidney Int 87(5), 10616%

Vertigo / dizziness 

(2015): Licht C+, Kidney Int 87(5), 10616%

(2013): Hillmen P+, Br J Haematol 162(1), 6220%

(2013): Rathbone J+, BMJ Open 3(11), Epub [REVIEW]11%

Abdominal pain 

(2021): Zhou S+, J Pediatr Hematol Oncol Apr, Online ahead of print [REVIEW]

(2013): Hillmen P+, Br J Haematol 162(1), 6222%

(2013): Rathbone J+, BMJ Open 3(11), Epub [REVIEW]11%

Constipation 

(2013): Hillmen P+, Br J Haematol 162(1), 6215%

Diarrhea 

(2021): Zhou S+, J Pediatr Hematol Oncol Apr, Online ahead of print [REVIEW]

(2015): Licht C+, Kidney Int 87(5), 10616%

(2013): Hillmen P+, Br J Haematol 162(1), 6235%

(2013): Rathbone J+, BMJ Open 3(11), Epub [REVIEW]32%

Nausea 

(2021): Zhou S+, J Pediatr Hematol Oncol Apr, Online ahead of print [REVIEW]

(2015): Licht C+, Kidney Int 87(5), 106112%

(2013): Hardinger KL+, World J Transplant 3(4), 68 [REVIEW]

(2013): Rathbone J+, BMJ Open 3(11), Epub [REVIEW]19%

(2008): Davis J, Am J Health Syst Pharm 65 (17), 1609

Peritonitis 

(2015): Licht C+, Kidney Int 87(5), 10615%

Vomiting  

(2015): Licht C+, Kidney Int 87(5), 106118%

(2013): Hillmen P+, Br J Haematol 162(1), 6226%

(2013): Rathbone J+, BMJ Open 3(11), Epub [REVIEW]21–22%

Hematuria 

(2015): Licht C+, Kidney Int 87(5), 10616%

Menorrhagia 

(2015): Licht C+, Kidney Int 87(5), 10615%

Urinary tract infection 

(2015): Licht C+, Kidney Int 87(5), 10616%

(2013): Hillmen P+, Br J Haematol 162(1), 6217%

(2013): Rathbone J+, BMJ Open 3(11), Epub [REVIEW]16%

Anemia 

(2015): Licht C+, Kidney Int 87(5), 10615%

(2013): Rathbone J+, BMJ Open 3(11), Epub [REVIEW]24%

Hemoglobin decreased 

(2015): Licht C+, Kidney Int 87(5), 10616%

Hemolysis 

(2012): Tomita A+, Ann Hematol 91(7), 1139

Hemolytic anemia 

(2017): Perez-De-Lis M+, Expert Opin Drug Saf 16(11), 1255 [REVIEW]

Hemotoxicity 

(2015): Licht C+, Kidney Int 87(5), 10615%

Leukocytopenia (leukopenia) 

(2015): Licht C+, Kidney Int 87(5), 106110%

(2013): Rathbone J+, BMJ Open 3(11), Epub [REVIEW]16%

Injection-site reaction 

(2015): Licht C+, Kidney Int 87(5), 106110%

Arthralgia 

(2013): Hillmen P+, Br J Haematol 162(1), 6222%

Asthenia / fatigue 12%

(2021): Zhou S+, J Pediatr Hematol Oncol Apr, Online ahead of print [REVIEW]

(2015): Licht C+, Kidney Int 87(5), 10615–6%

(2013): Hardinger KL+, World J Transplant 3(4), 68 [REVIEW]

(2013): Hillmen P+, Br J Haematol 162(1), 6213%

(2013): Rathbone J+, BMJ Open 3(11), Epub [REVIEW]11%

Back pain 19%

(2013): Hardinger KL+, World J Transplant 3(4), 68 [REVIEW]

(2013): Hillmen P+, Br J Haematol 162(1), 6225%

(2008): Davis J, Am J Health Syst Pharm 65 (17), 1609

Pain in extremities 

(2021): Zhou S+, J Pediatr Hematol Oncol Apr, Online ahead of print [REVIEW]

(2013): Hillmen P+, Br J Haematol 162(1), 6220%

(2013): Rathbone J+, BMJ Open 3(11), Epub [REVIEW]11%

Hearing loss (hypoacusis) 

(2015): Licht C+, Kidney Int 87(5), 10615%

Cough 12%

(2021): Zhou S+, J Pediatr Hematol Oncol Apr, Online ahead of print [REVIEW]

(2015): Licht C+, Kidney Int 87(5), 106110%

(2013): Hardinger KL+, World J Transplant 3(4), 68 [REVIEW]

(2013): Hillmen P+, Br J Haematol 162(1), 6220%

(2013): Rathbone J+, BMJ Open 3(11), Epub [REVIEW]14–26%

Flu-like syndrome 

(2013): Hillmen P+, Br J Haematol 162(1), 6217%

Influenza 

(2015): Licht C+, Kidney Int 87(5), 10615%

Nasopharyngitis 23%

(2021): Zhou S+, J Pediatr Hematol Oncol Apr, Online ahead of print [REVIEW]

(2015): Licht C+, Kidney Int 87(5), 10615%

(2013): Hardinger KL+, World J Transplant 3(4), 68 [REVIEW]

(2013): Hillmen P+, Br J Haematol 162(1), 6250%

(2013): Rathbone J+, BMJ Open 3(11), Epub [REVIEW]

(2008): Davis J, Am J Health Syst Pharm 65 (17), 1609

Pharyngolaryngeal pain 

(2015): Licht C+, Kidney Int 87(5), 10615%

(2013): Rathbone J+, BMJ Open 3(11), Epub [REVIEW]14%

Sinusitis 

(2013): Hillmen P+, Br J Haematol 162(1), 6212%

Upper respiratory tract infection 

(2021): Zhou S+, J Pediatr Hematol Oncol Apr, Online ahead of print [REVIEW]

(2017): Howard JF Jr+, Lancet Neurol 16(12), 97616%

(2013): Hillmen P+, Br J Haematol 162(1), 6241%

(2013): Rathbone J+, BMJ Open 3(11), Epub [REVIEW]32–35%

Adverse effects 

(2018): Kato H+, Clin Exp Nephrol Jun, Epub ahead of print

Infection 

(2015): Licht C+, Kidney Int 87(5), 10615%



Adverse reactions attributed to entire drug class Covid-19 putative drug

Cardiovascular adverse effect 

(2020): Carpenter A+, Front Cardiovasc Med 7, 85 [REVIEW]

(2020): Giudicessi JR+, Mayo Clin Proc May, Online ahead of print [REVIEW]

(2020): Naksuk N+, Eur Heart J Acute Cardiovasc Care May, Epub ahead of print [REVIEW]

(2020): Sarayani A+, Res Social Adm Pharm Apr, Epub ahead of print [REVIEW]

(2020): Zhang D+, Zhongguo Zhong Yao Za Zhi (Chinese) 45(10), 2275-2286 [REVIEW]

Neuropsychiatric / neuropsychological adverse effect 

(2021): Borah P+, Front Mol Biosci 8, 627723

(2020): García CAC+, Gen Hosp Psychiatry Jun, Online ahead of print [REVIEW]

Gastrointestinal disorder / discomfort 

(2020): Sun J+, Clin Pharmacol Ther Apr, Epub ahead of print23%

Thrombocytopenia 

(2020): Nham E+, Infect Chemother Apr, Epub ahead of print

Adverse effects 

(2021): Bérard A+, PLoS One 16(5), e0251746 [REVIEW] (in pregnancy)

(2021): Cheng Q+, Aging (Albany NY) Sep, Online ahead of print [REVIEW]

(2021): Cruciani F+, Recenti Prog Med 112(3), 195-206 [REVIEW]

(2021): Ommati MM+, J Biochem Mol Toxicol May, Online ahead of print [REVIEW]

(2021): Qiu R+, Medicine (Baltimore) 100(16), e25532 [REVIEW]

(2021): Wu SS+, Chin Med J (Engl) Jul, Online ahead of print [REVIEW]

(2020): Favilli A+, J Matern Fetal Neonatal Med Jun, Online ahead of print [REVIEW]

(2020): Griffiths G+, Trials 21(1), 544

(2020): Patil VM+, Life Sci May, Epub ahead of print [REVIEW]

(2020): Rhodes NJ+, medRxiv Jun, Preprint

(2020): Sun J+, Clin Pharmacol Ther Apr, Epub ahead of print38%

(2020): Svensson M, Lakartidningen (Swedish) Apr, 117

(2020): Wen CY+, Zhonghua Nei Ke Za Zhi (Chinese) May, Epub ahead of print

(2020): Zekarias A+, Drug Saf Sep, Online ahead of print [REVIEW]

(2020): Zhong H+, Pharmacol Res Apr, Epub ahead of print [REVIEW]

Page last updated 08/02/2021

Drug Eruption Mobile Site

Symbol key

Incidence info

  • <1%
  • 1-5%
  • 5-10%
  • 10-15%
  • 15-20%
  • 20-30%
  • >30%

Seriousness info

  • Hospitalization possible
  • Life threatening
  • Fatal

Warnings in other populations info

  • Breast feeding
  • Geriatric
  • Pediatric
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