Hydrochlorothiazide

  • TRADE NAME: Accuretic (Pfizer); Aldactazide (Pfizer); Aldoril (Merck); Apo-Hydro; Atacand HCT (AstraZeneca); Avalide (Bristol-Myers Squibb); Capozide (Par); Clothia; Dichlotride; Diovan (Novartis); Diu-Melsin; Diuchlor H; Dyazide (GSK); Esidrex; Hydrosaluric; Hyzaar (Merck); Inderide (Wyeth); Lopressor (Novartis); Lotensin (Novartis); Lotensin HCT (Novartis); Maxzide; Micardis (Boehringer Ingelheim); Microzide (Watson); Moduretic (Merck); Prinzide (Merck); Tekturna HCT (Novartis); Teveten HCT (Biovail); Uniretic (Schwarz); Urozide; Vaseretic (Biovail); Zestoretic (AstraZeneca); Ziac (Barr)
  • INDICATIONS: Edema
  • CLASS: Diuretic, thiazide
  • HALF-LIFE: 5.6–14.8 hours
CLINICALLY IMPORTANT, POTENTIALLY HAZARDOUS INTERACTIONS WITH:

Digoxin, Lithium, Zinc

PREGNANCY CATEGORY: B

NOTE

Hydrochlorothiazide is a sulfonamide and can be absorbed systemically. Sulfonamides can produce severe, possibly fatal, reactions such as toxic epidermal necrolysis and Stevens-Johnson syndrome

Hydrochlorothiazide is often used in combination, e.g. with aliskiren (Tekturna HCT); amiloride (Moduretic); benazepril (Lotensin HCT); bisoprolol (Ziac); captopril (Capozide); enalapril (Vaseretic); irbesartan (Avalide); lisinopril (Prinizide and Zestoretic); Losartan (Hyzaar); methyldopa (Aldoril); moexipril (Uniretic); spironolactone (Aldactazide); triamterene (Dyazide and Maxzide).

Our database has 42 adverse reactions for this drug across the following areas

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SKIN
MUCOSAL
CARDIOVASCULAR
CENTRAL NERVOUS SYSTEM
NEUROMUSCULAR/SKELETAL
GASTROINTESTINAL/HEPATIC
RESPIRATORY
ENDOCRINE/METABOLIC
HEMATOLOGIC
OCULAR
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Incidence info

  • <1%
  • 1-5%
  • 5-10%
  • 10-15%
  • 15-20%
  • 20-30%
  • >30%

Seriousness info

  • Hospitalization possible
  • Life Threatening
  • Fatal

Warnings in other populations info

  • Breast feeding
  • Geriatric
  • Pediatric