Diclofenac

BreastfeedingPediatric
  • TRADE NAMES: Allvoran; Apo-Diclo; Arthrotec (Pfizer); Cambia; Cataflam (Novartis); Dicolmax (Galen); Dyloject; Fenac; Flector Patch; Galedol; Liroken; Monoflam; Motifene (Daiichi Sankyo); Nu-Diclo; Pennsaid (Mallinckrodt); Remethan; Solaraze Gel (Nycomed); Taks; Voltaren (Novartis); Voltarene; Voltarol (Novartis); Zipsor (Depomed); Zorvolex
  • INDICATIONS: Rheumatoid and osteoarthritis, topical treatment of actinic keratosis; postoperative inflammation in patients who have undergone cataract extraction and for the temporary relief of pain and photophobia in patients undergoing corneal refractive surgery
  • CLASS: Non-steroidal anti-inflammatory (NSAID)
  • HALF-LIFE: 1–2 hours
CLINICALLY IMPORTANT, POTENTIALLY HAZARDOUS INTERACTIONS WITH:

ACE inhibitors, Adrenergic neurone blockers, Aldosterone antagonists, Aliskiren, Alpha blockers, Angiotensin II receptor antagonists, Anticoagulants, Aspirin, Baclofen, Beta blockers, Calcium channel blockers, Cardiac glycosides, Clonidine, Clopidogrel, Corticosteroids, Coumarins, Cyclosporine, Dabigatran, Deferiprone, Diazoxide, Diuretics, Enoxaparin, Erlotinib, Furosemide, Heparins, Hydralazine, Iloprost, Ketorolac, Lithium, Methotrexate, Methyldopa, Mifamurtide, Minoxidil, Moxonidine, Nitrates, Nitroprusside, Penicillamine, Pentoxifylline, Phenindione, Potassium canrenoate, Prasugrel, Rifampin, Ritonavir, Rivaroxaban, SSRIs, Sulfonylureas, Tacrolimus, Thiazides, Tinzaparin, Venlafaxine, Voriconazole, Warfarin, Zidovudine

PREGNANCY CATEGORY: D
category B for topical use; category C for oral and ophthalmic use; category D in third trimester.

NSAIDs may cause an increased risk of serious cardiovascular and gastrointestinal adverse events, which can be fatal. This risk may increase with duration of use.

Contra-indicated in patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs. Severe, rarely fatal, anaphylactic-like reactions to NSAIDs have been reported in such patients.

Arthrotec is diclofenac and misoprostol.

RISK OF SERIOUS CARDIOVASCULAR AND GASTROINTESTINAL EVENTS

See full prescribing information for complete boxed warning.

Our database has 117 adverse reactions for this drug across the following areas

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SKIN
HAIR
NAILS
MUCOSAL
CARDIOVASCULAR
CENTRAL NERVOUS SYSTEM
ENDOCRINE/METABOLIC
GASTROINTESTINAL/HEPATIC
GENITOURINARY
HEMATOLOGIC
LOCAL
NEUROMUSCULAR/SKELETAL
OCULAR
RENAL
RESPIRATORY
OTHER


Visit Informa

Click on the DRUG REVIEW ARTICLE tab (above) to see a review of low-dose diclofenac in the Taylor & Francis journal Expert Opinion on Drug Safety. (Note that non-subscribers to the journal will only be able to see an abstract of the article.)

Page last updated 02/18/2019

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Incidence info

  • <1%
  • 1-5%
  • 5-10%
  • 10-15%
  • 15-20%
  • 20-30%
  • >30%

Seriousness info

  • Hospitalization possible
  • Life threatening
  • Fatal

Warnings in other populations info

  • Breast feeding
  • Geriatric
  • Pediatric