Abstract
An 83-year-old woman was admitted to our hospital with abdominal pain. Examination revealed mediastinal lymphoadenopathy, hepatosplenomegaly, and infiltration of abnormal cells into the bone marrow with hemophagocytosis, and CD5-positive diffuse large B cell lymphoma was diagnosed. Chemotherapy was administered and progressive weakness of the limbs, resembling a Guillain-Barré-like syndrome, subsequently appeared. Cerebrospinal fluid examination indicated lymphoma cell infiltration. Although immune globulin and steroid therapies were not effective, intrathecal injection of methotrexate, predonisolone, and cytarabine improved these symptoms. Subsequent to chemotherapy, cell surface antigen changes were observed in the cerebrospinal fluid relative to those in bone marrow.
MeSH terms
-
Aged, 80 and over
-
Antigens, Neoplasm / genetics
-
Antigens, Neoplasm / immunology
-
Antineoplastic Combined Chemotherapy Protocols*
-
CD5 Antigens / genetics
-
CD5 Antigens / immunology*
-
Cell Movement
-
Central Nervous System / drug effects
-
Central Nervous System / immunology
-
Central Nervous System / pathology*
-
Cytarabine / administration & dosage
-
Female
-
Guillain-Barre Syndrome / drug therapy
-
Guillain-Barre Syndrome / etiology
-
Guillain-Barre Syndrome / immunology
-
Guillain-Barre Syndrome / pathology
-
Humans
-
Immunoglobulins, Intravenous / adverse effects
-
Lymphoma, Large B-Cell, Diffuse / cerebrospinal fluid
-
Lymphoma, Large B-Cell, Diffuse / drug therapy
-
Lymphoma, Large B-Cell, Diffuse / immunology
-
Lymphoma, Large B-Cell, Diffuse / pathology*
-
Methotrexate / administration & dosage
-
Prednisolone / administration & dosage
-
Steroids / adverse effects
Substances
-
Antigens, Neoplasm
-
CD5 Antigens
-
Immunoglobulins, Intravenous
-
Steroids
-
Cytarabine
-
Prednisolone
-
Methotrexate