Short Communication: Resolution of Tenofovir Disoproxil Fumarate Induced Fanconi Syndrome with Switch to Tenofovir Alafenamide Fumarate in a HIV-1 and Hepatitis B Coinfected Patient

AIDS Res Hum Retroviruses. 2017 Jul;33(7):718-722. doi: 10.1089/AID.2016.0180. Epub 2017 May 12.

Abstract

Fanconi syndrome is a rare adverse effect of tenofovir disoproxil fumarate (TDF). Tenofovir alafenamide fumarate (TAF) is a novel prodrug with less nephrotoxicity. We report resolution of Fanconi syndrome in a HIV and hepatitis B coinfected patient switched from TDF to TAF.

Keywords: Fanconi syndrome; HIV; hepatitis B; tenofovir alafenamide.

Publication types

  • Case Reports

MeSH terms

  • Adenine / administration & dosage
  • Adenine / analogs & derivatives*
  • Alanine
  • Anti-HIV Agents / administration & dosage*
  • Anti-HIV Agents / adverse effects*
  • Coinfection / complications
  • Coinfection / drug therapy
  • Fanconi Syndrome / chemically induced*
  • HIV Infections / complications*
  • HIV Infections / drug therapy
  • Hepatitis B, Chronic / complications*
  • Humans
  • Male
  • Middle Aged
  • Tenofovir / administration & dosage
  • Tenofovir / adverse effects*
  • Treatment Outcome

Substances

  • Anti-HIV Agents
  • Tenofovir
  • tenofovir alafenamide
  • Adenine
  • Alanine