Abstract
A single pill daily fixed dose combination of Efavirenz, Emtricitabine, and Tenofovir Disoproxil Fumarate (EFV/FTC/TDF) provides a potent and convenient treatment option for HIV/AIDS. The components have been shown to be well tolerated and are effective in randomized controlled trials. A literature search revealed no case of hepatic failure reported with this drug combination. We here in describe the 1st case of acute hepatic failure developing after 3 months of treatment with EFV/FTC/TDF in a 41 year old African American male without pre-existing liver disease or risk factors.
MeSH terms
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Adenine / adverse effects
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Adenine / analogs & derivatives*
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Adult
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Deoxycytidine / adverse effects
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Deoxycytidine / analogs & derivatives*
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Drug Combinations
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Efavirenz, Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination
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HIV Infections / drug therapy
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Humans
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Liver Failure / chemically induced*
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Male
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Organophosphonates / adverse effects*
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Oxazines / adverse effects*
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Reverse Transcriptase Inhibitors / adverse effects*
Substances
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Drug Combinations
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Efavirenz, Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination
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Organophosphonates
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Oxazines
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Reverse Transcriptase Inhibitors
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Deoxycytidine
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Adenine