Abstract
Proteinuria was observed in 27% of 153 patients taking tenofovir for more than 1 year. Concomitant protease inhibitor therapy and cumulative tenofovir exposure were independently associated with proteinuria in this cohort. Proteinuria was reversible in 11 of 12 patients who ceased tenofovir because of proteinuria without altering other medications. Clinicians should be aware that tenofovir can cause reversible proteinuria in patients with HIV.
MeSH terms
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Adenine / administration & dosage
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Adenine / adverse effects
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Adenine / analogs & derivatives*
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Anti-HIV Agents / administration & dosage
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Anti-HIV Agents / adverse effects*
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Creatine / urine*
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Female
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HIV Infections / drug therapy*
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Humans
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Male
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Middle Aged
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Organophosphonates / administration & dosage
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Organophosphonates / adverse effects*
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Proteinuria / chemically induced*
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Proteinuria / urine
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Renal Insufficiency, Chronic / chemically induced*
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Renal Insufficiency, Chronic / urine
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Tenofovir
Substances
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Anti-HIV Agents
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Organophosphonates
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Tenofovir
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Adenine
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Creatine