Abstract
Drug-induced renal failure is a relatively common event in patients infected with HIV. This group of patients receives a number of potentially nephrotoxic medications for a variety of illnesses. The acyclic nucleoside phosphonates cidofovir and adefovir are antivirals that possess significant nephrotoxicity. Interestingly, tenofovir disoproxil fumurate (DF) is structurally similar to these 2 agents, yet seems to be less nephrotoxic based on a few published studies in HIV patients with intact renal function. We present a case in which acute renal failure developed after therapy with tenofovir DF in a patient with HIV and stable chronic kidney disease.
MeSH terms
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Acute Kidney Injury / chemically induced*
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Acute Kidney Injury / pathology
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Acute Kidney Injury / physiopathology
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Adenine / adverse effects*
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Adenine / analogs & derivatives*
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Adenine / therapeutic use
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Adult
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Anti-HIV Agents / adverse effects*
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Anti-HIV Agents / therapeutic use
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Chronic Disease
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HIV Infections / complications
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HIV Infections / drug therapy
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Humans
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Kidney / pathology
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Kidney / physiopathology
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Kidney Diseases / complications
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Male
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Organophosphonates*
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Organophosphorus Compounds / adverse effects*
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Organophosphorus Compounds / therapeutic use
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Tenofovir
Substances
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Anti-HIV Agents
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Organophosphonates
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Organophosphorus Compounds
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Tenofovir
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Adenine