Irreversible sensorineural hearing loss due to Imatinib

Leuk Res. 2008 Jun;32(6):991-2. doi: 10.1016/j.leukres.2007.11.039. Epub 2008 Jan 25.

Abstract

Objective: We report probably the first case of bilateral irreversible sensorineural hearing loss caused by Imatinib.

Method: A review of the world literature, concerning Imatinib toxicity is presented.

Results: We report a case of bilateral irreversible sensorineural hearing loss, in a 19-year-old male patient of chronic myeloid leukemia after 3 months of Imatinib therapy. Audiometric evaluation documented the findings.

Conclusion: To the best of our knowledge, this is the first case report of Imatinib induced sensorineural hearing loss. This case indicates that treating oncologists should keep in mind that this drug too can produce ototoxicity.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Benzamides
  • Hearing Loss, Sensorineural / chemically induced*
  • Humans
  • Imatinib Mesylate
  • In Situ Hybridization, Fluorescence
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / complications
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / drug therapy
  • Male
  • Piperazines / adverse effects*
  • Protein Kinase Inhibitors / adverse effects*
  • Protein-Tyrosine Kinases / antagonists & inhibitors
  • Pyrimidines / adverse effects*

Substances

  • Benzamides
  • Piperazines
  • Protein Kinase Inhibitors
  • Pyrimidines
  • Imatinib Mesylate
  • Protein-Tyrosine Kinases