Abstract
Iatrogenic causes for palpebral edema are rarely suspected and must be specifically sought. The authors report a case of palpebral edema in a patient treated with a specific inhibitor of the BCR-ABL tyrosine kinase (Glivec) for chronic myeloid leukemia. Histopathological analysis of specimens of the excised upper eyelid tissue revealed the absence of leukemic infiltration, suggesting the toxic effect of the treatment. This side effect should be noted so that patients are informed and biopsy is proposed to eliminate tumoral infiltration.
Publication types
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Case Reports
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English Abstract
MeSH terms
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Aged
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Antineoplastic Agents / adverse effects*
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Antineoplastic Agents / antagonists & inhibitors
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Benzamides
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Biopsy
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Diagnosis, Differential
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Edema / chemically induced*
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Edema / diagnosis
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Edema / pathology
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Eyelid Diseases / chemically induced*
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Eyelid Diseases / diagnosis
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Eyelid Diseases / pathology
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Eyelids / pathology
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Female
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Humans
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Iatrogenic Disease
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Imatinib Mesylate
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Leukemia, Myelogenous, Chronic, BCR-ABL Positive / drug therapy
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Piperazines / administration & dosage
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Piperazines / adverse effects*
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Protein-Tyrosine Kinases / antagonists & inhibitors*
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Pyrimidines / administration & dosage
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Pyrimidines / adverse effects*
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Time Factors
Substances
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Antineoplastic Agents
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Benzamides
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Piperazines
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Pyrimidines
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Imatinib Mesylate
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Protein-Tyrosine Kinases