[Perianesthetic refractory anaphylactic shock with cefuroxime in a patient with history of penicillin allergy on multiple antihypertensive medications]

Rev Bras Anestesiol. 2017 Mar-Apr;67(2):217-220. doi: 10.1016/j.bjan.2014.08.003. Epub 2015 Mar 6.
[Article in Portuguese]

Abstract

We report a case of perianesthetic refractory anaphylactic shock with cefuroxime in a patient with history of penicillin allergy on regular therapy with atenolol, losartan, prazosin and nicardipine. Severe anaphylactic shock was only transiently responsive to 10mL of (1:10000) epinephrine and needed norepinephrine and dopamine infusion. Supportive therapy with vasopressors and inotropes along with mechanical ventilation for the next 24hours resulted in complete recovery. She was successfully operated upon 2 weeks later with the same anesthetic drugs but intravenous ciprofloxacin as the alternative antibiotic for perioperative prophylaxis.

Keywords: Anafilaxia; Anaphylaxis; Cefuroxima; Cefuroxime; Perianesthetic; Perianestésico.

Publication types

  • Case Reports

MeSH terms

  • Anaphylaxis / chemically induced*
  • Anesthesia
  • Anti-Bacterial Agents / adverse effects*
  • Antihypertensive Agents / therapeutic use
  • Cefuroxime / adverse effects*
  • Drug Hypersensitivity / complications
  • Drug Hypersensitivity / etiology
  • Drug Therapy, Combination
  • Female
  • Humans
  • Middle Aged
  • Penicillins / adverse effects
  • Severity of Illness Index

Substances

  • Anti-Bacterial Agents
  • Antihypertensive Agents
  • Penicillins
  • Cefuroxime