Abstract
A 70-year-old woman with chronic hepatitis C was admitted to our hospital due to liver injury, cholecystitis, and disseminated intravascular coagulation with a fever and skin rash. She had been on a combination regimen of daclatasvir and asunaprevir for 2 weeks of a 24-week regimen. Because of the symptoms, laboratory findings, results of a drug-induced lymphocyte stimulation test, and pathological findings of liver biopsy, we diagnosed her with drug-induced liver injury. Although daclatasvir and asunaprevir combination therapy is generally well-tolerated, some serious adverse effects have been reported. Our findings indicate that immunoallergic mechanisms were associated with daclatasvir and asunaprevir-induced liver injury.
MeSH terms
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Aged
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Antiviral Agents / adverse effects*
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Antiviral Agents / therapeutic use
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Asian People
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Carbamates
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Chemical and Drug Induced Liver Injury / blood
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Chemical and Drug Induced Liver Injury / drug therapy*
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Cholecystitis / chemically induced*
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Cholecystitis / complications
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Combined Modality Therapy
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Drug Therapy, Combination
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Female
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Genotype
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Hepatitis C, Chronic / complications
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Hepatitis C, Chronic / drug therapy*
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Humans
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Imidazoles / administration & dosage
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Imidazoles / adverse effects*
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Imidazoles / therapeutic use
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Isoquinolines / administration & dosage
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Isoquinolines / adverse effects*
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Isoquinolines / therapeutic use
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Pyrrolidines
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Sulfonamides / administration & dosage
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Sulfonamides / adverse effects*
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Sulfonamides / therapeutic use
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Treatment Outcome
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Valine / analogs & derivatives
Substances
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Antiviral Agents
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Carbamates
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Imidazoles
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Isoquinolines
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Pyrrolidines
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Sulfonamides
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Valine
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daclatasvir
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asunaprevir