Acute vanishing bile duct syndrome after ibuprofen therapy in a child

J Pediatr. 2004 Aug;145(2):273-6. doi: 10.1016/j.jpeds.2004.05.027.

Abstract

We report the case of a 10 year-old girl who had Stevens-Johnson syndrome and cholestasis after ibuprofen therapy. Liver histology was compatible with vanishing bile duct syndrome. She received ursodeoxycholic acid, and liver tests normalized within 7 months. This report confirms that ibuprofen may induce acute vanishing bile duct syndrome.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Acute Disease
  • Anti-Inflammatory Agents, Non-Steroidal / adverse effects*
  • Bile Duct Diseases / chemically induced*
  • Bile Duct Diseases / pathology
  • Bile Ducts, Intrahepatic* / pathology
  • Child
  • Cholestasis / chemically induced
  • Female
  • Humans
  • Ibuprofen / adverse effects*
  • Stevens-Johnson Syndrome / chemically induced
  • Syndrome

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Ibuprofen