Suspected Hydroxychloroquine-Induced Sinus Bradycardia and QTc Prolongation in a Patient with COVID-19

Int Heart J. 2020 Sep 29;61(5):1056-1058. doi: 10.1536/ihj.20-271. Epub 2020 Sep 12.

Abstract

An 84-year-old woman with hypertension, Alzheimer's disease, and chronic kidney disease presented with fever and was diagnosed with corona virus disease 2019 (COVID-19). During the hospitalization, she experienced unexpected sinus bradycardia with prolonged QTc, which was thought to be closely related to the short-term use of hydroxychloroquine (HCQ), an old drug used to treat malaria and autoimmune diseases, but now used against COVID-19. The cardiac side effects of HCQ were rare, seen with short-term and low-dose use. With the COVID-19 pandemic, this case alerts clinicians to be aware of the arrhythmogenic effects of HCQ when it is used as an antiviral drug, especially in patients with preexisting cardiovascular diseases.

Keywords: Adverse effects; Antiviral agents; Coronavirus infections.

Publication types

  • Case Reports

MeSH terms

  • Aged, 80 and over
  • Betacoronavirus*
  • Bradycardia / chemically induced*
  • COVID-19
  • COVID-19 Drug Treatment
  • Coronavirus Infections / drug therapy*
  • Female
  • Humans
  • Hydroxychloroquine / adverse effects*
  • Long QT Syndrome / chemically induced*
  • Pandemics
  • Pneumonia, Viral / drug therapy*
  • SARS-CoV-2

Substances

  • Hydroxychloroquine