Purpose: Several case reports have highlighted symptomatic hypoglycemia as a serious but uncommon adverse effect of hydroxychloroquine (HCQ) in nondiabetic subjects.
Methods: This study describes a nondiabetic patient who experienced serious hypoglycemia related to HCQ.
Findings: In the course of treatment, the patient experienced multiple episodes of hypoglycemia at night and in the early morning. The hypoglycemia was usually accompanied by nausea, fatigue, and dizziness. The lowest value of blood glucose in the fingertip was 2.6 mmol/L.
Implications: This rare case will prompt clinicians to pay attention to unexplained hypoglycemia when using HCQ in nondiabetic patients.
Keywords: Connective tissue disease; Gastrointestinal bleeding; Hydroxychloroquine; Hypoglycemia.
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