Hydroxychloroquine-induced acute generalized exanthematous pustulosis with positive patch-testing

Indian J Pharmacol. 2015 Nov-Dec;47(6):693-4. doi: 10.4103/0253-7613.169589.

Abstract

Acute generalized exanthematous pustulosis (AGEP) is a severe cutaneous adverse reaction, mostly induced by drugs. Hydroxychloroquine have been rarely reported in literature as a causative drug of this reaction. We report a case of AGEP induced by hydroxychloroquine with systemic involvement and confirmed by positive patch testing.

Keywords: Hydroxychloroquine; patch test; pustulosis.

Publication types

  • Case Reports

MeSH terms

  • Acute Generalized Exanthematous Pustulosis / diagnosis
  • Acute Generalized Exanthematous Pustulosis / etiology*
  • Adult
  • Anti-Inflammatory Agents, Non-Steroidal / adverse effects*
  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
  • Arthralgia / etiology
  • Arthralgia / prevention & control
  • Chloroquine / adverse effects
  • Chloroquine / therapeutic use
  • Drug Monitoring
  • Drug Resistance
  • Drug Therapy, Combination / adverse effects
  • Female
  • Humans
  • Hydroxychloroquine / adverse effects*
  • Hydroxychloroquine / therapeutic use
  • Lupus Erythematosus, Systemic / drug therapy
  • Lupus Erythematosus, Systemic / physiopathology
  • Patch Tests
  • Prednisolone / adverse effects
  • Prednisolone / therapeutic use

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Hydroxychloroquine
  • Chloroquine
  • Prednisolone