Antimalarials in dermatology: mechanism of action, indications, and side effects

C Rodriguez-Caruncho; I Bielsa Marsol

doi:10.1016/j.adengl.2012.10.021

Antimalarials in dermatology: mechanism of action, indications, and side effects

Actas Dermosifiliogr. 2014 Apr;105(3):243-52. doi: 10.1016/j.adengl.2012.10.021. Epub 2014 Mar 18.

Authors

C Rodriguez-Caruncho¹, I Bielsa Marsol²

Affiliations

¹ Servicio de Dermatología, Hospital Universitari Germans Trias i Pujol, Universitat Autónoma de Badalona, Badalona, Barcelona, Spain. Electronic address: clararodriguezc@yahoo.es.
² Servicio de Dermatología, Hospital Universitari Germans Trias i Pujol, Universitat Autónoma de Badalona, Badalona, Barcelona, Spain.

PMID: 24656224
DOI: 10.1016/j.adengl.2012.10.021

Abstract

Antimalarial drugs have been in common use in dermatology since the 1950s. Their mechanism of action is complex, and it is now known that they act through various pathways. We review the indications for antimalarials in dermatology, their adverse effects, and some less well-known effects, such as their antithrombotic and hypolipidemic action. The most recent recommendations concerning ophthalmological screening in patients on antimalarials are also reviewed.

Keywords: Antimalarials; Antipalúdicos; Chloroquine; Cloroquina; Hidroxicloroquina; Hydroxychloroquine; Lupus eritematoso; Lupus erythematosus.

Publication types

Review

MeSH terms

Antimalarials / adverse effects
Antimalarials / pharmacology*
Antimalarials / therapeutic use*
Humans
Skin Diseases / drug therapy*

Substances

Antimalarials