Cutaneous necrosis caused by systemically administered heparin

JAMA. 1981 Oct 2;246(14):1582-3.

Abstract

Two cases of cutaneous necrosis occurred that were caused by intravenous administration of porcine heparin for deep venous thrombophlebitis. The lesions grossly resembled those of warfarin sodium-induced skin necrosis. However, histologically, no fibrin thrombi were noted in capillaries and vessels, a characteristic finding in warfarin necrosis. There was no evidence of vasculitis in the lesions. Both patients subsequently received warfarin without complications.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Heparin / adverse effects*
  • Humans
  • Injections, Intravenous
  • Male
  • Middle Aged
  • Necrosis
  • Skin / pathology
  • Skin Diseases, Vesiculobullous / chemically induced*
  • Thrombophlebitis / drug therapy

Substances

  • Heparin