Cerebral venous thrombosis and heparin-induced thrombocytopenia in an 18-year old male with severe ulcerative colitis

World J Gastroenterol. 2008 Jul 28;14(28):4576-9. doi: 10.3748/wjg.14.4576.

Abstract

The risk of thromboembolism is increased in inflammatory bowel disease and its symptoms may be overlooked. Furthermore, its treatment can be complex and is not without complications. We describe a case of an adolescent boy who developed a cerebral sinus venous thrombosis during a relapse of his ulcerative colitis and who, while on treatment with heparin, developed heparin-induced thrombocytopenia (HIT). The treatment was then switched to fondaparinux, a synthetic and selective inhibitor of activated factor X.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Colitis, Ulcerative / complications*
  • Fondaparinux
  • Heparin / adverse effects*
  • Heparin / therapeutic use*
  • Humans
  • Intracranial Thrombosis / drug therapy*
  • Intracranial Thrombosis / epidemiology
  • Male
  • Polysaccharides / therapeutic use
  • Risk Factors
  • Thrombocytopenia / chemically induced*
  • Thrombocytopenia / diagnosis
  • Venous Thrombosis / drug therapy*
  • Venous Thrombosis / epidemiology

Substances

  • Polysaccharides
  • Heparin
  • Fondaparinux