Heparin-induced thrombocytopenia complicating hemodialysis

M F Barginear; L Donahue; S L Allen; D R Budman; T Bradley; M Bhaskaran; I Shapira

doi:10.1177/1076029607304405

Heparin-induced thrombocytopenia complicating hemodialysis

Clin Appl Thromb Hemost. 2008 Jan;14(1):105-7. doi: 10.1177/1076029607304405. Epub 2007 Dec 26.

Authors

M F Barginear¹, L Donahue, S L Allen, D R Budman, T Bradley, M Bhaskaran, I Shapira

Affiliation

¹ Don Monti Division of Medical Oncology/Division of Hematology, North Shore University Hospital, New York University School of Medicine, New York 11042, USA. m_barginear@hotmail.com

PMID: 18160608
DOI: 10.1177/1076029607304405

Abstract

Hemodialysis complicated by heparin-induced thrombocytopenia (HIT) is a rare event requiring anticoagulation with direct-thrombin inhibitors. Contaminant calcific uremic arteriolopathy (calciphylaxis) further complicates this situation due to the possibility that warfarin anticoagulation may exacerbate skin necrosis. The authors report a patient with renal failure and calciphylaxis who developed HIT after starting hemodialysis. She was successfully treated with Argatroban.

Publication types

Case Reports

MeSH terms

Adult
Anticoagulants / therapeutic use
Arginine / analogs & derivatives
Calciphylaxis / pathology*
Drug Contamination
Female
Heparin
Humans
Necrosis / chemically induced
Pipecolic Acids / therapeutic use
Renal Dialysis
Renal Insufficiency / complications*
Skin Diseases / chemically induced
Skin Diseases / pathology
Sulfonamides
Thrombocytopenia / chemically induced*
Thrombocytopenia / drug therapy
Warfarin / adverse effects

Substances

Anticoagulants
Pipecolic Acids
Sulfonamides
Warfarin
Heparin
Arginine
argatroban