Bullous hemorrhagic dermatosis occurring at sites distant from subcutaneous injections of heparin: three cases

Adeline Perrinaud; David Jacobi; Marie-Christine Machet; Claire Grodet; Yves Gruel; Laurent Machet

doi:10.1016/j.jaad.2005.01.098

Bullous hemorrhagic dermatosis occurring at sites distant from subcutaneous injections of heparin: three cases

J Am Acad Dermatol. 2006 Feb;54(2 Suppl):S5-7. doi: 10.1016/j.jaad.2005.01.098.

Authors

Adeline Perrinaud¹, David Jacobi, Marie-Christine Machet, Claire Grodet, Yves Gruel, Laurent Machet

Affiliation

¹ Department of Dermatology, Université François-Rabelais, University Hospital of Tours, Tours, France.

PMID: 16427995
DOI: 10.1016/j.jaad.2005.01.098

Abstract

Cutaneous side effects from heparin administration are rare and usually located at injection sites. We report 3 cases of intraepidermal hemorrhagic blisters occurring distant from sites of subcutaneous injections of heparin. A causative link is suggested by a temporal relationship between heparin introduction and onset of disease as well as exclusion of other causes, but the mechanism remains unknown.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Aged
Aged, 80 and over
Anticoagulants / adverse effects*
Female
Hemorrhage / chemically induced
Heparin / adverse effects*
Humans
Injections, Subcutaneous
Male
Middle Aged
Skin Diseases / chemically induced*
Skin Diseases / pathology
Skin Diseases, Vesiculobullous / chemically induced*
Skin Diseases, Vesiculobullous / pathology

Substances

Anticoagulants
Heparin