Felty's syndrome treated with rhG-CSF associated with flare of arthritis and skin rash

Clin Rheumatol. 1995 Mar;14(2):204-8. doi: 10.1007/BF02214945.

Abstract

A patient with Felty's syndrome and rheumatoid arthritis was treated with recombinant granulocyte stimulating factor rhG-CSF (Neupogen) in view of severe neutropenia. He had a prompt rise in his neutrophil count and associated with this a severe flare of his arthritis and a skin rash. rhG-CSF was stopped, his neutrophil count fell rapidly and his symptoms resolved. rhG-CSF and the resulting rise in neutrophil count may be associated with flare of autoimmune disease in susceptible individuals.

Publication types

  • Case Reports

MeSH terms

  • Arthritis, Rheumatoid / complications*
  • Arthritis, Rheumatoid / physiopathology
  • Drug Eruptions / etiology*
  • Felty Syndrome / complications*
  • Felty Syndrome / drug therapy*
  • Felty Syndrome / physiopathology
  • Filgrastim
  • Granulocyte Colony-Stimulating Factor / adverse effects*
  • Granulocyte Colony-Stimulating Factor / therapeutic use
  • Humans
  • Male
  • Middle Aged
  • Neutropenia / drug therapy*
  • Neutropenia / etiology
  • Recombinant Proteins / adverse effects
  • Recombinant Proteins / therapeutic use

Substances

  • Recombinant Proteins
  • Granulocyte Colony-Stimulating Factor
  • Filgrastim