Abstract
A patient with Felty's syndrome and rheumatoid arthritis was treated with recombinant granulocyte stimulating factor rhG-CSF (Neupogen) in view of severe neutropenia. He had a prompt rise in his neutrophil count and associated with this a severe flare of his arthritis and a skin rash. rhG-CSF was stopped, his neutrophil count fell rapidly and his symptoms resolved. rhG-CSF and the resulting rise in neutrophil count may be associated with flare of autoimmune disease in susceptible individuals.
MeSH terms
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Arthritis, Rheumatoid / complications*
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Arthritis, Rheumatoid / physiopathology
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Drug Eruptions / etiology*
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Felty Syndrome / complications*
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Felty Syndrome / drug therapy*
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Felty Syndrome / physiopathology
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Filgrastim
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Granulocyte Colony-Stimulating Factor / adverse effects*
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Granulocyte Colony-Stimulating Factor / therapeutic use
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Humans
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Male
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Middle Aged
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Neutropenia / drug therapy*
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Neutropenia / etiology
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Recombinant Proteins / adverse effects
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Recombinant Proteins / therapeutic use
Substances
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Recombinant Proteins
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Granulocyte Colony-Stimulating Factor
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Filgrastim