Abstract
A 71-year-old female with advanced endometrial cancer was treated with pegfilgrastim. She developed a fever within seven days, and contrast-enhanced computed tomography scans repeated within three days revealed rapidly progressive thickening of the aortic wall. When clinicians administer PEGylated granulocyte-colony stimulating factor (G-CSF) to cancer patients, drug-associated vasculitis should be suspected. This report discusses the manifestation of G-CSF-associated large-vessel vasculitis (LVV).
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Aged
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Aorta, Thoracic / diagnostic imaging*
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Endometrial Neoplasms* / pathology
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Endometrial Neoplasms* / therapy
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Female
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Filgrastim* / administration & dosage
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Filgrastim* / adverse effects
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Giant Cell Arteritis* / diagnosis
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Giant Cell Arteritis* / etiology
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Giant Cell Arteritis* / therapy
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Glucocorticoids / administration & dosage
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Hematologic Agents / administration & dosage
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Hematologic Agents / adverse effects
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Humans
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Neoplasm Staging
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Neutropenia* / chemically induced
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Neutropenia* / diagnosis
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Neutropenia* / drug therapy
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Polyethylene Glycols* / administration & dosage
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Polyethylene Glycols* / adverse effects
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Positron Emission Tomography Computed Tomography / methods
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Prednisolone / administration & dosage*
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Radiographic Image Enhancement / methods
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Treatment Outcome
Substances
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Glucocorticoids
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Hematologic Agents
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pegfilgrastim
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Polyethylene Glycols
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Prednisolone
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Filgrastim