Erythroderma with lichenoid granulomatous features induced by erythropoietin

J Cutan Pathol. 2005 May;32(5):371-4. doi: 10.1111/j.0303-6987.2005.00327.x.

Abstract

The increasing use of new drugs in cancer therapy, especially growth factors, hormones, and chemotherapies resulted in several reports of unusual skin eruptions. We studied a patient with erythroderma who had received erythropoietin because of myeloma with tumor anemia. The histological features were characterized by a lichenoid, focally granulomatous infiltrate with predominance of histiocytes. It is important for dermatopathologists to recognize this interesting pattern induced by erythropoietin.

Publication types

  • Case Reports

MeSH terms

  • Anemia / drug therapy
  • Anemia / etiology
  • Antigens, CD / metabolism
  • Dermatitis, Exfoliative / chemically induced*
  • Dermatitis, Exfoliative / metabolism
  • Dermatitis, Exfoliative / pathology*
  • Erythropoietin / adverse effects*
  • Erythropoietin / therapeutic use
  • Granuloma / pathology*
  • Histiocytes / metabolism
  • Histiocytes / pathology
  • Humans
  • Lichenoid Eruptions / pathology*
  • Male
  • Middle Aged
  • Multiple Myeloma / complications
  • T-Lymphocytes / metabolism
  • T-Lymphocytes / pathology

Substances

  • Antigens, CD
  • Erythropoietin