Abstract
The increasing use of new drugs in cancer therapy, especially growth factors, hormones, and chemotherapies resulted in several reports of unusual skin eruptions. We studied a patient with erythroderma who had received erythropoietin because of myeloma with tumor anemia. The histological features were characterized by a lichenoid, focally granulomatous infiltrate with predominance of histiocytes. It is important for dermatopathologists to recognize this interesting pattern induced by erythropoietin.
MeSH terms
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Anemia / drug therapy
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Anemia / etiology
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Antigens, CD / metabolism
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Dermatitis, Exfoliative / chemically induced*
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Dermatitis, Exfoliative / metabolism
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Dermatitis, Exfoliative / pathology*
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Erythropoietin / adverse effects*
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Erythropoietin / therapeutic use
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Granuloma / pathology*
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Histiocytes / metabolism
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Histiocytes / pathology
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Humans
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Lichenoid Eruptions / pathology*
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Male
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Middle Aged
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Multiple Myeloma / complications
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T-Lymphocytes / metabolism
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T-Lymphocytes / pathology
Substances
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Antigens, CD
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Erythropoietin