Kaposi sarcoma in a fingolimod-treated patient with multiple sclerosis

J Clin Neurosci. 2016 Sep:31:217-8. doi: 10.1016/j.jocn.2016.03.001. Epub 2016 May 8.

Abstract

Kaposi sarcoma (KS) is a vascular tumour of endothelial cell origin, associated with human herpes virus 8. It develops in one of four clinical settings, one of which is iatrogenic immunosuppression. We present the case of a 46year-old man with relapsing-remitting multiple sclerosis who developed KS in the context of fingolimod use. To our knowledge, this is the second reported case of KS in a fingolimod-treated individual. This case highlights potential risks associated with immunosuppression with this medicine and ongoing need for vigilance in assessing for such complications.

Keywords: Adverse effect; Fingolimod; Kaposi sarcoma; Malignancy; Multiple sclerosis.

Publication types

  • Case Reports

MeSH terms

  • Fingolimod Hydrochloride / adverse effects*
  • Fingolimod Hydrochloride / therapeutic use
  • Humans
  • Immunosuppressive Agents / adverse effects*
  • Immunosuppressive Agents / therapeutic use
  • Male
  • Middle Aged
  • Multiple Sclerosis, Relapsing-Remitting / complications
  • Multiple Sclerosis, Relapsing-Remitting / drug therapy*
  • Sarcoma, Kaposi / complications
  • Sarcoma, Kaposi / etiology*

Substances

  • Immunosuppressive Agents
  • Fingolimod Hydrochloride