Abstract
Abnormalities of the gastrointestinal tract due to drug-induced injuries are common and often have important clinical consequences. Medications may cause damage by direct corrosive effects on mucosae or by alter processes, mucosal immunity, and local environmental conditions. The aim of this review is to guide practicing pathologists in the identification of drug-related injuries in gastrointestinal mucosal biopsies and resection specimens. Common causes of injury and their gross, endoscopic, and microscopic features are presented.
Keywords:
Colchicine; Kayexalate; Mycophenolate mofetil; Olmesartan; Paclitaxel; Tetracycline.
Copyright © 2014 Elsevier Inc. All rights reserved.
MeSH terms
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Alendronate / adverse effects
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Angiotensin II Type 1 Receptor Blockers / adverse effects
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Anti-Inflammatory Agents / adverse effects
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Antineoplastic Agents, Phytogenic / adverse effects
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Bone Density Conservation Agents / adverse effects
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Cation Exchange Resins / adverse effects
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Colchicine / adverse effects
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Ferrous Compounds / adverse effects
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Gastrointestinal Diseases / chemically induced*
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Gastrointestinal Diseases / pathology
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Gastrointestinal Tract / drug effects
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Gastrointestinal Tract / pathology*
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Gout Suppressants / adverse effects
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Humans
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Imidazoles / adverse effects
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Immunosuppressive Agents / adverse effects
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Mycophenolic Acid / adverse effects
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Mycophenolic Acid / analogs & derivatives
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Paclitaxel / adverse effects
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Polystyrenes / adverse effects
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Tetracycline / adverse effects
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Tetrazoles / adverse effects
Substances
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Angiotensin II Type 1 Receptor Blockers
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Anti-Inflammatory Agents
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Antineoplastic Agents, Phytogenic
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Bone Density Conservation Agents
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Cation Exchange Resins
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Ferrous Compounds
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Gout Suppressants
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Imidazoles
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Immunosuppressive Agents
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Polystyrenes
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Tetrazoles
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ferrous sulfate
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polystyrene sulfonic acid
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olmesartan
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Tetracycline
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Mycophenolic Acid
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Paclitaxel
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Colchicine
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Alendronate