Attention has once again been directed to the very uncomfortable itching following chloroquine chemotherapy of malaria in about 8% of the Nigeria population. Six typical case reports are presented. We have been able to identify three stages in the course of the itching and in the second stage, four phases have been outlined. The major implications of the pruritus are briefly discussed in respect to its effect on malaria treatment. Its possible link with more serious adverse effects and variations in drug metabolism are also mentioned. The treatment outlined is directed towards minimizing the intensity and duration of the itching reaction.