Chloroquine-induced hypopigmentation of hair and freckles. Association with congenital renal failure

Arch Dermatol. 1985 Sep;121(9):1164-6. doi: 10.1001/archderm.1985.01660090078018.

Abstract

Hypopigmentation of hair and freckles occurred in a patient receiving chloroquine sulfate therapy. This patient had a severe congenital renal failure that presumably increased plasma and tissue levels of the drug substantially, accounting for the hypopigmentation.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Chloroquine / adverse effects*
  • Chloroquine / metabolism
  • Female
  • Hair / pathology
  • Hair Color*
  • Humans
  • Kidney Failure, Chronic / complications
  • Kidney Failure, Chronic / congenital
  • Kidney Failure, Chronic / metabolism
  • Melanosis / pathology*
  • Pigmentation Disorders / chemically induced*

Substances

  • Chloroquine