Abstract
Tenofovir is recommended as one of the first line agents in combination with other antiretroviral drugs for management of human immunodeficiency virus (HIV). It is known to cause renal failure after exposure for a median duration of 5 months. We report tenofovir induced adverse drug reaction in a 56-year-old female patient who was diagnosed to have HIV 1 infection since 10 years. The combination antiretroviral treatment included tenofovir, emtricitabine and ritonavir/lopinavir regimen since the last 6 years. She presented with recent onset renal failure and renal biopsy showed interstitial nephritis which could probably attributable to tenofovir.
Keywords:
Human immunodeficiency virus; renal failure; tenofovir.
MeSH terms
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Adenine / administration & dosage
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Adenine / adverse effects
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Adenine / analogs & derivatives*
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Adenine / therapeutic use
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Anti-HIV Agents / administration & dosage
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Anti-HIV Agents / adverse effects*
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Anti-HIV Agents / therapeutic use
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Biopsy
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Diagnosis, Differential
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Female
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HIV Infections / drug therapy
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HIV Infections / virology
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Humans
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Kidney / drug effects*
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Kidney / pathology
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Middle Aged
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Nephritis, Interstitial / chemically induced*
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Nephritis, Interstitial / pathology
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Organophosphonates / administration & dosage
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Organophosphonates / adverse effects*
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Organophosphonates / therapeutic use
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Renal Insufficiency / chemically induced*
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Renal Insufficiency / pathology
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Tenofovir
Substances
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Anti-HIV Agents
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Organophosphonates
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Tenofovir
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Adenine