Twin preterm neonates with cardiac toxicity related to lopinavir/ritonavir therapy

Monica A McArthur; Stella U Kalu; Arlen R Foulks; Ashraf M Aly; Sunil K Jain; Janak A Patel

doi:10.1097/INF.0b013e3181acd17e

Twin preterm neonates with cardiac toxicity related to lopinavir/ritonavir therapy

Pediatr Infect Dis J. 2009 Dec;28(12):1127-9. doi: 10.1097/INF.0b013e3181acd17e.

Authors

Monica A McArthur¹, Stella U Kalu, Arlen R Foulks, Ashraf M Aly, Sunil K Jain, Janak A Patel

Affiliation

¹ Department of Pediatrics, The University of Texas Medical Branch, Galveston, TX 77555-0371, USA.

PMID: 19820426
DOI: 10.1097/INF.0b013e3181acd17e

Abstract

We report twin neonates who were born prematurely at 32 weeks of gestation to a mother with human immunodeficiency virus infection. One of the twins developed complete heart block and dilated cardiomyopathy related to lopinavir/ritonavir therapy, a boosted protease-inhibitor agent, while the other twin developed mild bradycardia. We recommend caution in the use of lopinavir/ritonavir in the immediate neonatal period.

Publication types

Case Reports

MeSH terms

Diseases in Twins / chemically induced
Electrocardiography
Female
HIV Protease Inhibitors / adverse effects*
HIV Protease Inhibitors / therapeutic use
Heart / drug effects*
Heart Block
Heart Diseases / chemically induced*
Humans
Infant, Newborn
Infant, Premature*
Infectious Disease Transmission, Vertical / prevention & control
Lopinavir
Pyrimidinones / adverse effects*
Pyrimidinones / therapeutic use
Ritonavir / adverse effects*
Ritonavir / therapeutic use
Twins*

Substances

HIV Protease Inhibitors
Pyrimidinones
Lopinavir
Ritonavir