Background: Cutaneous reactions to BCG have rarely been a problem and BCG is one of the safest vaccines in use.
Case report: Two children, 6 and 7 years old, developed local tuberculosis lupus 7 and 8 months, respectively, after BCG vaccination. Cutaneous changes cured after a treatment with isoniazid for 9 months in one case with observance of the treatment was uncertain in the other.
Conclusion: Tuberculosis lupus is a rare complication of BCG vaccination. Its clinical features are identical to those of the vulgaris lupus. The diagnosis is based on clinical, pathology aspects and anamnesia. This complication should not be a contra-indication of BCG immunization.