BCG vaccine-induced lupus vulgaris

Arch Dermatol. 1982 Mar;118(3):171-2.

Abstract

A case of intradermal BCG vaccination was complicated by a lupus-like tuberculosis cutis progressive for over 30 years. The patient had been vaccinated twice with BCG in the affected site. A review of other BCG vaccine-induced cases of lupus vulgaris indicates that the incidence of this complication is markedly increased following multiple BCG vaccinations, but is rare following a single BCG vaccination. In our patient a skin biopsy specimen was characteristic for lupus vulgaris. Acid-fast stains from the tissue and cultures from the affected site were negative. The patient was successfully treated with rifampin.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • BCG Vaccine / adverse effects*
  • Female
  • Humans
  • Lupus Vulgaris / drug therapy
  • Lupus Vulgaris / etiology*
  • Lupus Vulgaris / pathology
  • Prednisone / administration & dosage
  • Rifampin / administration & dosage

Substances

  • BCG Vaccine
  • Prednisone
  • Rifampin