Bacille Calmette-Guérin Vaccine-Induced Tuberculous Hip Osteomyelitis in an Infant: Case report

Sultan Qaboos Univ Med J. 2017 Aug;17(3):e358-e362. doi: 10.18295/squmj.2017.17.03.019. Epub 2017 Oct 10.

Abstract

To this day, tuberculosis (TB) continues to pose a significant global health burden. The World Health Organization's Expanded Programme on Immunization (EPI) recommends the bacille Calmette-Guérin (BCG) vaccine for infants to protect against the haematogenous spread of primary TB and other more severe types of TB infection. We report an eight-month-old boy who presented to the Armed Forces Hospital, Muscat, Oman, in 2015 with a one-month history of intermittent fever associated with a limited range of motion in the right hip area. He was up-to-date with his EPI vaccinations and had no history of exposure to individuals with TB infections. He was initially treated for bacterial septic arthritis; however, a GeneXpert TB assay revealed the presence of Mycobacterium tuberculosis, BCG strain. To the best of the authors' knowledge, this is the first documented case from Oman of a child with TB hip osteomyelitis due to a BCG vaccination.

Keywords: BCG Vaccine; Case Report; Oman; Osteomyelitis; Tuberculosis; Vaccination; adverse effects.

Publication types

  • Case Reports

MeSH terms

  • Adjuvants, Immunologic / adverse effects*
  • BCG Vaccine / adverse effects*
  • Hip Joint / microbiology*
  • Humans
  • Infant
  • Male
  • Mycobacterium bovis*
  • Oman
  • Osteomyelitis / diagnosis
  • Osteomyelitis / microbiology*
  • Tuberculosis, Osteoarticular / diagnosis
  • Tuberculosis, Osteoarticular / microbiology*

Substances

  • Adjuvants, Immunologic
  • BCG Vaccine