[Effects of Dexamethasone, Fluorometholone and Florex on intraocular pressure after photorefractive keratectomy]

Hua Xi Yi Ke Da Xue Xue Bao. 1999 Jun;30(2):205-7.
[Article in Chinese]

Abstract

To evaluate the results of elevated intraocular pressure (IO) secondary to dropping of 0.1% Dexamethasone, Fluorometholone and Florex for 1-3 months after photorefractive keratectomy, we summed up and analysed the 3-month follow-up data on 546 eyes in three groups. The rates of IO elevated in Dexamethasone, Fluorometholone and Florex were 36%, 12.4% and 31.9% respectively. After topical use of corticosteroid, some of the elevations of IO took place as early as two weeks, but most of them occurred around 1 month. Eleven patients with IO elevation of both eyes had visual acuity decreased associated with eye-ache and halos and the other patients had no symptoms. After discontinuation of corticosteroid and institution of antiglaucoma therapy, the IO became normal in 3-7 days. In practice, this means that patients receiving corticosteroid eyedrops for more than two weeks should be checked for the possibility of ocular hypertension to prevent the corticosteroid glaucoma.

Publication types

  • English Abstract

MeSH terms

  • Administration, Topical
  • Adolescent
  • Adult
  • Anti-Inflammatory Agents / administration & dosage
  • Anti-Inflammatory Agents / adverse effects*
  • Dexamethasone / administration & dosage
  • Dexamethasone / adverse effects*
  • Female
  • Fluorometholone / administration & dosage
  • Fluorometholone / adverse effects*
  • Flurogestone Acetate / administration & dosage
  • Flurogestone Acetate / adverse effects
  • Follow-Up Studies
  • Glaucoma / chemically induced
  • Glucocorticoids
  • Humans
  • Intraocular Pressure
  • Lasers, Excimer
  • Male
  • Middle Aged
  • Ophthalmic Solutions
  • Photorefractive Keratectomy*
  • Postoperative Care

Substances

  • Anti-Inflammatory Agents
  • Glucocorticoids
  • Ophthalmic Solutions
  • Dexamethasone
  • Fluorometholone
  • Flurogestone Acetate