The aim of this research is, to show the action mechanism of metyloprednizolon and the side--effects of the Solu-Medrol application in the treatment of demyelinization neuritis of ophtalmic nerve in sclerosis multiplex. In research, there were described the side-effects after second Solu-Medrol bolus dose given to a 44-year-old patient. She has suffered from SM and demyelinization neuritis of ophtalmic nerve with rapid deterioration of visual acuity for 14 years. In the years 1995-2002 there has not been any case of side-effects similar to this patient's, among all the 30 other patients treated with Solu-Medrol. It confirms the usefulness of bolus dose metyloprednizolon therapy applied to patients suffering from ophtalmic nerve demyelinization with rapid deterioration of visual acuity.