Abstract
Stevens-Johnson syndrome (SJS) is a vesiculobullous disease of the skin and mucosa. This generalized hypersensitivity reaction is well known to occur in association with certain drugs, particularly sulfonamides, nonsteroidal anti-inflammatory agents (NSAIDs), and anticonvulsants. The disease is usually seen in children and young adults and is often treated with corticosteroids. We present a 9-year-old girl with lupus nephritis who developed cutaneous bullae and mucositis while being treated with intravenous methylprednisolone. The initial differential diagnosis included bullous lupus, but skin biopsy specimen findings supported a diagnosis of SJS. She was treated with intravenous immunoglobulin (IVIg).
MeSH terms
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Child
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Diagnosis, Differential
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Drug Hypersensitivity / diagnosis
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Drug Hypersensitivity / etiology
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Female
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Glucocorticoids / administration & dosage
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Glucocorticoids / adverse effects*
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Humans
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Immunoglobulins, Intravenous / therapeutic use
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Infusions, Intravenous
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Lupus Erythematosus, Systemic / drug therapy*
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Lupus Erythematosus, Systemic / genetics
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Lupus Nephritis / drug therapy
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Methylprednisolone Hemisuccinate / administration & dosage
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Methylprednisolone Hemisuccinate / adverse effects*
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Stevens-Johnson Syndrome / chemically induced*
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Stevens-Johnson Syndrome / diagnosis
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Stevens-Johnson Syndrome / therapy
Substances
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Glucocorticoids
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Immunoglobulins, Intravenous
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Methylprednisolone Hemisuccinate