Older adults have increased risk for depression, and the use of selective serotonin reuptake inhibitors (SSRIs) is common. Serotonin syndrome is a potential adverse event associated with the use of SSRIs, the combination of SSRIs and trazodone, and the combination of SSRIs and linezolid. Pharmacists are ideal for assessing older adult drug regimens and recognizing potential drug interactions associated with proserotonergic drugs and alleviating adverse events for patients.