An Overview of Nonsteroidal Antiinflammatory Drug Reactions

Kristen M Walters; Katharine M Woessner

doi:10.1016/j.iac.2016.06.001

An Overview of Nonsteroidal Antiinflammatory Drug Reactions

Immunol Allergy Clin North Am. 2016 Nov;36(4):625-641. doi: 10.1016/j.iac.2016.06.001.

Authors

Kristen M Walters¹, Katharine M Woessner²

Affiliations

¹ Department of Allergy, Asthma & Immunology, Scripps Clinic, 3811 Valley Centre Drive, San Diego, CA 92130, USA.
² Department of Allergy, Asthma & Immunology, Scripps Clinic, 3811 Valley Centre Drive, San Diego, CA 92130, USA. Electronic address: Woessner.katharine@scrippshealth.org.

PMID: 27712759
DOI: 10.1016/j.iac.2016.06.001

Abstract

Nonsteroidal antiinflammatory drugs (NSAIDs), including aspirin, are among the most commonly used drugs worldwide. They account for a large number of adverse drug reactions (ADRs). The prevalence of NSAID-induced reactions is increasing. Distinguishing between a predicted side effect of a drug and a potentially life-threatening hypersensitivity reaction is essential to manage the affected patient. However, most clinicians find it difficult to diagnose these types of reactions despite published classification schemes. In this overview, we provide an in-depth review of NSAID classification, types of NSAID reactions, diagnostic tactics, and management strategies to provide the reader with a greater understanding of NSAID-induced reactions.

Keywords: Aspirin intolerance; Drug allergy; NSAID hypersensitivity; NSAID reactions; NSAID-induced asthma; NSAID-induced urticaria; Nonsteroidal antiinflammatory drugs (NSAIDs).

Publication types

Review

MeSH terms

Anti-Inflammatory Agents, Non-Steroidal / adverse effects*
Anti-Inflammatory Agents, Non-Steroidal / classification
Disease Management
Drug Hypersensitivity / diagnosis*
Drug Hypersensitivity / etiology*
Drug Hypersensitivity / therapy*
Humans

Substances

Anti-Inflammatory Agents, Non-Steroidal