Immune checkpoint inhibitor (ICI) has been proven to be a major breakthrough in the treatment of various tumor types. Despite the favorable results in terms of oncological outcomes, these treatments have been associated with a variety of immune-related adverse events (irAEs). Myasthenia gravis (MG) is one of rare but life-threatening irAEs, with acute onset and rapid progression after ICI initiation. Early diagnosis and active treatment are crucial. Herein, we review recent literatures to provide guidance to frequently asked questions concerning the diagnosis and management of ICI-MG.
【中文题目：免疫检查点抑制剂相关性重症肌无力： 从诊断到治疗】 【中文摘要：已经证实免疫检查点抑制剂（immune checkpoint inhibitor, ICI）使多种肿瘤的治疗有了翻天覆地的变化。尽管治疗的有效性让人欣慰，但是这些治疗也造成了多样化的免疫治疗相关的不良反应（immune-related adverse events, irAEs）。重症肌无力（myasthenia gravis, MG）就是一种罕见且危及生命的irAE，通常在ICI治疗后急性发病并迅速进展。早期诊断和积极的治疗非常重要。在此，我们对近几年的相关文献进行了复习和整理，针对ICI-MG诊断和治疗相关的常见问题提供参考意见。】 【中文关键词：免疫检查点抑制剂；重症肌无力；外周神经病变；免疫治疗不良反应】.
Keywords: Immune checkpoint inhibitor; Immune-related adverse events; Myasthenia gravis; Peripheral neuropathy.