Incidence of antiemetic-induced akathisia in patients at a comprehensive cancer center

Psychooncology. 2018 Apr;27(4):1338-1340. doi: 10.1002/pon.4597. Epub 2017 Dec 7.

Abstract

Introduction: Akathisia is a common and severely disabling medication-induced movement disorder. The condition is often missed, and patients suffer for a long time until diagnosed and managed properly. It is important to bring awareness to the clinicians for early detection and management of akathisia.

Methods: We reviewed a 4-year record of patients seen at a comprehensive cancer center for anxiety and restlessness. Patients diagnosed with akathisia and the medications causing akathisia were identified. Management of akathisia is discussed.

Results: The results showed that 4.7% of patients developed akathisia while taking antiemetic agents to control chemotherapy-induced nausea/vomiting. Early detection and management of akathisia resulted in quick recovery and reduced patients' suffering.

Conclusion: Akathisia is an unpleasant feeling of motor restlessness with anxiety. Clinicians need to have a full understanding to identify the subtle difference between functional anxiety and akathisia.

Keywords: akathisia; antiemetic drugs; anxiety; cancer patients; chemotherapy; movement disorder; oncology setting; restlessness.

MeSH terms

  • Akathisia, Drug-Induced / drug therapy
  • Akathisia, Drug-Induced / epidemiology*
  • Akathisia, Drug-Induced / etiology*
  • Antiemetics / administration & dosage*
  • Antiemetics / therapeutic use
  • Antineoplastic Agents / adverse effects*
  • Antineoplastic Agents / therapeutic use
  • Female
  • Humans
  • Incidence
  • Male
  • Middle Aged
  • Nausea / chemically induced
  • Psychomotor Agitation
  • Vomiting / chemically induced

Substances

  • Antiemetics
  • Antineoplastic Agents