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Patients receiving concomitant capecitabine and oral coumarin-derivative anticoagulants such as warfarin and phenprocoumon should have their anticoagulant response (INR or prothrombin time) monitored frequently in order to adjust the anticoagulant dose accordingly. Altered coagulation parameters and/or bleeding, including death, have been reported during concomitant use.
Contra-indicated in patients with severe renal impairment or with known hypersensitivity to fluorouracil.
Capecitabine is a prodrug of 5-fluorouracil.
XELODA - WARFARIN INTERACTION
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