Physostigmine

Breastfeeding
  • TRADE NAMES: Antilirium; Isopto Eserine
  • INDICATIONS: Miotic in glaucoma treatment; reverses toxic CNS effects caused by anticholinergic drugs
  • SYNONYM: eserine
  • CLASS: Cholinesterase inhibitor
  • HALF-LIFE: 15–40 minutes
CLINICALLY IMPORTANT, POTENTIALLY HAZARDOUS INTERACTIONS WITH:

Bethanechol, Corticosteroids, Galantamine, Methacholine, Succinylcholine

PREGNANCY CATEGORY: C

Antilirium is a derivative of the Calabar bean, and its active moiety, physostigmine, is also known as eserine. Physostigmine is used to reverse the effect upon the nervous system caused by clinical or toxic dosages of drugs and herbs capable of producing the anticholinergic syndrome. Some of the drugs responsible are: amitriptyline, amoxapine, atropine, benztropine, biperiden, clidinium, cyclobenzaprine, desipramine, doxepin, hyoscyamine, imipramine, lorazepam, maprotiline, nortriptyline, protriptyline, propantheline, scopolamine, trimipramine. Some herbals that can elicit the anticholinergic syndrome are black henbane, deadly nightshade, Devil's apple, Jimson weed, Loco seeds or weeds, Matrimony vine, night blooming jessamine, stinkweed.

Our database has 20 adverse reactions for this drug across the following areas

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SKIN
MUCOSAL
CARDIOVASCULAR
CENTRAL NERVOUS SYSTEM
GASTROINTESTINAL/HEPATIC
OCULAR
RESPIRATORY
OTHER


Page last updated 09/19/2018

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Incidence info

  • <1%
  • 1-5%
  • 5-10%
  • 10-15%
  • 15-20%
  • 20-30%
  • >30%

Seriousness info

  • Hospitalization possible
  • Life threatening
  • Fatal

Warnings in other populations info

  • Breast feeding
  • Geriatric
  • Pediatric
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