Uracil/Tegafur
- TRADE NAME: Uftoral (Bristol-Myers Squibb)
- INDICATIONS: Metastatic colorectal cancer
- CLASS: Antimetabolite, Folic acid antagonist
- HALF-LIFE: 6.5 hours
CLINICALLY IMPORTANT, POTENTIALLY HAZARDOUS INTERACTIONS WITH:
Allopurinol, Cimetidine, Clozapine, Metronidazole, Phenytoin, Tegafur/Gimeracil/Oteracil, Warfarin
PREGNANCY CATEGORY: D
Tegafur is a prodrug of fluorouracil (see separate entry).
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SKIN.
NAILS.
MUCOSAL.
CARDIOVASCULAR.
CENTRAL NERVOUS SYSTEM.
ENDOCRINE/METABOLIC.
GASTROINTESTINAL/HEPATIC.
HEMATOLOGIC.
NEUROMUSCULAR/SKELETAL.
OCULAR.
RESPIRATORY.
OTHER.
Page last updated 07/31/2023
Symbol key
Incidence
- <1%
- 1-5%
- 5-10%
- 10-15%
- 15-20%
- 20-30%
- >30%
Warnings in other populations
- Breast feeding
- Geriatric
- Pediatric