Management of side effects of mTOR inhibitors in tuberous sclerosis patients

Pharmacol Rep. 2016 Jun;68(3):536-42. doi: 10.1016/j.pharep.2016.01.005. Epub 2016 Jan 22.

Abstract

mTOR inhibitors represent a relatively new therapeutic option in the management of patients affected by tuberous sclerosis complex (TSC). Randomized clinical trials support the use of everolimus in the treatment of subependymal giant cell astrocytomas (SEGA) and renal angiomyolipomas (AML) related to TSC. Accumulating data suggest also systemic disease-modifying potential of mTOR inhibitors. Given that increasing number of patients with TSC receive mTOR inhibitors, the issue of adverse events associated with this therapy becomes practically important. In the present study we provide the overview of clinical manifestations and therapeutic options for the most common adverse events related to mTOR inhibitors in TSC patients.

Keywords: Everolimus; Sirolimus; Tuberous sclerosis complex; mTOR inhibitors.

Publication types

  • Review

MeSH terms

  • Disease Management
  • Everolimus / adverse effects*
  • Humans
  • Protein Kinase Inhibitors / adverse effects
  • Protein Kinase Inhibitors / therapeutic use
  • Sirolimus / adverse effects*
  • TOR Serine-Threonine Kinases / antagonists & inhibitors*
  • Tuberous Sclerosis / drug therapy*

Substances

  • Protein Kinase Inhibitors
  • Everolimus
  • MTOR protein, human
  • TOR Serine-Threonine Kinases
  • Sirolimus