Chemotherapy-Induced Oral Complications and Prophylaxis Strategies

Cancer Invest. 2023 May;41(5):432-455. doi: 10.1080/07357907.2023.2188558. Epub 2023 Apr 20.

Abstract

Cancer is currently a significant therapeutic challenge and is frequently connected with numerous adverse effects. Despite many improvements in chemotherapy, oral complications are common, leading to poor quality of life and chemotherapeutic dose reduction, which impair survival. This review summarizes the most common dental complications in patients receiving chemotherapy. We mainly focus on oral mucositis as it is a major cause of dose-limiting toxicity. Furthermore, oral candidiasis, viral infections, and xerostomia will be discussed. Conclusions: preventing complications is significantly more important than treating them. All patients beginning systemic anticancer treatment should undergo a thorough oral examination and get appropriate prophylaxis.

Keywords: Chemotherapy toxicity; mucositis; oral complication; oral health care; prevention action.

Publication types

  • Review

MeSH terms

  • Antineoplastic Agents* / adverse effects
  • Candidiasis, Oral* / chemically induced
  • Candidiasis, Oral* / drug therapy
  • Candidiasis, Oral* / prevention & control
  • Humans
  • Neoplasms* / therapy
  • Quality of Life
  • Stomatitis* / chemically induced
  • Stomatitis* / drug therapy
  • Stomatitis* / prevention & control

Substances

  • Antineoplastic Agents