Help

Click a help option below for more details:

Log in to your account
Search overview
Understanding the drug data – drug profiles and drug reactions
References
Compare drugs
In brief
Subscribe
About Informa Healthcare and how to contact us

------------------------------------------------------------------------------------------------

Log in to your account

You need to subscribe to the Litt’s D.E.R.M. Database online to have full access to the site. If you are not yet a subscriber and would like a demonstration of the site, please contact Oliver.Holroyd-Pearce@informa.com

If you are a subscriber, on the opening page enter your User Name and Password (in the frame on the top right) and then click Login. Passwords are allocated when you complete your subscription details. In case you have forgotten your password, you can use the ‘forgotten password’ function.
Login now.

For login and database access queries, please email OnlineAccess@informa.com and use Litt's D.E.R.M. database in the subject of your email.

------------------------------------------------------------------------------------------------

Search overview

Once you have logged in you can search information by typing a term into the search box and choosing the relevant search category option from the drop-down list on the right of the search box. There are six main search categories in this drop-down list:

i) Drug Name
ii) Adverse Reaction
iii) Drug Class
iv) Herbal
v) Reaction Category
vi) Company

Once you have entered a search term, picked the search category, and pressed ‘GO’, this will bring up the results corresponding to your query. Clicking on any name in this sub-list will give you full details of the relevant search term.

i) Searching for Drug Name brings up generic and/or trade name drugs, which if clicked on, reveal the entire drug profile for that drug.

ii) Searching for an Adverse Reaction brings up drug reactions and eruptions. When a reaction is clicked on, this brings up a page where there may be a description of the reaction/eruption in question along with images (if any) of that reaction. From this page, you will also be able to bring up a list of all drugs that are known to cause that particular reaction.

iii) Searching for a Drug Class will bring up the names of drug classes which, when clicked on, will list the drugs on the database that belong to that class of drugs. The individual drug profiles for the drugs within this drug class can then be viewed.

iv) Herbals, too, are profiled on this database. Searching for Herbals brings up a listing of the relevant herbals, which if clicked on, reveal the entire profile for that herbal product.

v) A Reaction Category search brings up a list of areas or systems within the body that may be affected by a drug reaction (e.g., Skin, Cardiovascular, Mucosal, Central nervous system etc). Clicking on one of these reaction categories brings up a list of all reactions/eruptions documented on the database within that area/system.

Thus, for example, all cutaneous eruptions are classified under ‘Skin’, all drug-reactions affecting the cardiac system are classified under ‘Cardiovascular, and so on.

vi) If you search for a Company, and click on the company name from the list of results, you will then be presented with a list of drugs where the trade named products are manufactured or owned by that company. From the listing of the drugs thus belonging to a company, you can click through to the corresponding drug profile.

TIPS:

Active links on the site are blue, and clicking on these will lead to other areas of the site.
At the top of each drug profile is the option to compare this drug to any other drug on the site.

Demonstrations/guided tours of the website can be arranged for you or your department - please email support@drugeruptiondata.com if this would be of interest. There is no charge for this service.

------------------------------------------------------------------------------------------------

Understanding the drug data

DRUG PROFILE

The bulk of the data on this database in contained within the detailed description of drugs and their associated adverse reactions. These are listed together on the drug profile pages.

On any such drug profile page:

• The generic drug name is at the top.
• The most common trade (brand) name(s) are listed alphabetically (with the manufacturer in brackets).
• This is followed by the indications, the class to which the drug belongs, and the half-life (where known).
• The potentially hazardous interactions section lists hazardous interactions between the chosen drug and other prescription and over-the-counter drugs. Clicking on a drug listed within the ‘interactions’ section will reveal full details of that drug.
• The pregnancy category for the drug follows, if applicable.
• Special warnings and clinically relevant notes (including black box warnings, if applicable) are also included for each drug profile.
• At the top of each drug profile is the option to compare this drug with any other drug on the site.

The above information about any drug will then be followed by a list of Drug Reactions.

DRUG REACTIONS

Reactions listed within any drug profile are those adverse reactions and cutaneous eruptions that could arise as a result of the particular generic drug. These reactions are classified into the following categories:
• Skin
• Hair
• Nails
• Mucosal
• Cardiovascular
• Central Nervous System
• Neuromuscular/Skeletal
• Gastrointestinal/Hepatic
• Respiratory
• Endocrine/Metabolic
• Genitourinary
• Renal
• Hematologic
• Otic
• Ocular
• Local
• Other

Clicking on any of the reactions will take you to a page that may contain a brief description and, sometimes, images of that particular reaction pattern. From this page, you can bring up a list of all drugs that are known to cause that reaction.

There are occasions when there are very few adverse reactions to a specific drug. These drugs are still included in the Database since there is often a positive significance in negative findings.

DRUG REVIEW ARTICLE

A new green tab at the end of a drug profile indicates that there is a review or safety evaluation of this drug in the Informa Healthcare journal Expert Opinion on Drug Safety. Clicking on this tab will open the Summary page for the relevant article. Drugs which have this link include:
• Acamprosate
• Acitretin
• Adalimumab
• Adefovir
• Amiodarone
• Amlodipine
• Amoxicillin
• Anastrozole
• Aprepitant
• Aripiprozole
• Atorvastatin
• Bivalirudin (NEW)
• Brimonidine
• Candesartan
• Capecitabine
• Clopidogrel
• Colesevelam
• Darbepoetin Alfa
• Dronedarone
• Duloxetine
• Efalizumab
• Enoxaparin
• Erlotinib
• Etanercept (NEW)
• Everolimus
• Exemestane
• Ezetimibe
• Famciclovir
• Fesoterodine
• Fluvastatin
• Fulvestrant
• Gefitinib
• Ixabepilone
• Lapatinib
• Lenalidomide (NEW)
• Linezolid
• Memantine
• Mycophenolate
• Nilotinib
• Octreotide
• Omalizumab
• Orlistat
• Oseltamivir
• Oxymorphone
• Pemetrexed
• Pioglitazone
• Rabeprazole
• Ranibizumab
• Rasagiline
• Remifentanil
• Rituximab
• Rivastigmine
• Rosuvastatin
• Simvastatin
• Tacrolimus
• Telbivudine
• Temozolomide
• Tiotropium
• Tirofiban
• Tocilizumab
• Trastuzumab
• Valsartan
• Varenicline
• Vinorelbine
• Ziprasidone
• Zoledronic Acid
• Zonisamide

------------------------------------------------------------------------------------------------

References and links to PubMed/Medline

This database has over 58,000 links to references - both research papers and reviews. References are listed on drug-profile pages and serve as peer-reviewed evidence for reporting a certain adverse reaction to that drug. Where there are more than one, the most recent citation appears at the top of the list.

As a departure from conventional style, reference listings are formatted in the following order:

The year appears first, in parentheses.
Last name and initial(s) of the principal author follows. A plus sign after the author's name denotes one or more co-authors.
Journal name (standard abbreviation where possible) is in italics.
Volume number and the first page of the article come next.
Books, when cited, include the publisher and page number.
Internet articles and other sources, when cited, give as much information as is available to us.

Click on the date and/or author to link out to the Abstract of that paper on PubMed/Medline, which should open in a new window.
Review articles are highlighted as such at the end of the reference.

Other notes

Percentages or percentage ranges in coloured boxes after a reaction indicate the incidence or prevalence of the listed reactions. These are essentially vague and should be viewed in the context of the detailed references. The key to the colour coding for these percentage values is available on the right hand side of the screen.

Logos depicted and described in the symbol key to the right of the page represent warnings in special populations if these appear at the top of any drug profile.

------------------------------------------------------------------------------------------------

Compare drugs

The compare drugs function is new to the Litt’s D.E.R.M. Database. This allows you to compare up to four drug profiles in both a graphical and tabular format.

Drugs can be selected for comparison during detailed searches or through individual drug profiles.
For a more detailed description of this tool click here.

------------------------------------------------------------------------------------------------

In brief...

Subscribers can register to use the Litt DERM database on a smart phone for ease of reference in multiple office or clinical locations at no extra charge [Click on the ‘Litt’s mobile’ heading tag in the toolbar above]
The database offers a quick function of bringing up all drugs related to a particular adverse reaction/eruption [Click on the relevant entry in the opening ‘Adverse reaction’ menu; and then the box for ‘View other drugs that may cause …’]
You can also search the database by drug, reaction system category, drug class, or pharmaceutical company, depending on your current requirement [Click on the relevant entry in the particular opening menu]
You can use a compare function to produce a simple graph comparing up to four drugs in terms of their reaction profile [Use the ‘Compare this drug to’ box; and then the ‘Add drug’ line as required]
There are descriptions (together with images, where available) for important reaction patterns [Click on the relevant entry in the ‘Adverse reaction’ menu]
Specific patient populations at risk are noted, and there is an explicit pregnancy category rating [Automatic: top of ‘Drug’ reaction profile]
The reactions have color coding and a color flag system to alert you to the incidence and seriousness [Automatic in ‘Drug’ reaction profile]
You can save the results of a search for future reference [Click the ‘Save this search’ box]
You can connect to PubMed for the abstract of an article cited to open in a separate box; there are now over 50 000 such links [Click the reference in the Drug profile]
You can request to be alerted about up to five drugs you have a particular interest in following [Click on the relevant entry in the opening ‘Drugs’ menu; and then the ‘Watch this Drug’ box at the top right of the entry]
A weekly alert summarizes the new and changed drug profiles [Automatic; you can unsubscribe under the ‘Alerts’ heading tag]
A monthly newsletter summarizes important new research and trends, particularly in dermatology [Automatic; you can unsubscribe under the ‘Alerts’ heading tag]
Users are encouraged to contribute adverse reactions [Email us at support@eruptiondata.com]

------------------------------------------------------------------------------------------------

this form

------------------------------------------------------------------------------------------------

About Informa Healthcare and how to contact us

For Customer Services and login-related queries, please email subscriptions@informa.com
For questions, comments and feedback on the database content, please email support@drugeruptiondata.com

From its offices in New York and London, Informa Healthcare produces a wide range of specialist information across various subjects and in different formats: from primary data sources such as books, journals, databases and newsletters to a range of bespoke publications, videos, slide sets and multimedia software for healthcare professionals around the world.

Informa Healthcare's authors and editors are among the leaders in medical science, and many of our publications document the notable contributions they have made to their own specialist fields. See http://informahealthcare.com or http://informahealthcarebooks.com.

Informa Healthcare
UK: 1-2 Bolt Court, London EC4A 3DQ
USA: 52 Vanderbilt Avenue, New York, NY 10017
http://www.informahealthcare.com
http://www.informahealthcarebooks.com