Sirolimus
- TRADE NAME: Rapamune (Wyeth)
- INDICATIONS: Prophylaxis of organ rejection in renal transplants
- SYNONYM: Rapamycin
- CLASS: Antibiotic, macrolide, Immunosuppressant, Non-calcineurin inhibitor
- HALF-LIFE: 62 hours
CLINICALLY IMPORTANT, POTENTIALLY HAZARDOUS INTERACTIONS WITH:
Atazanavir, Benazepril, Boceprevir, Captopril, Crizotinib, Cyclosporine, Delavirdine, Dronedarone, Enalapril, Fosinopril, Hemophilus B vaccine, Indinavir, Itraconazole, Lisinopril, Lopinavir, Micafungin, Mifepristone, Quinapril, Ramipril, St John's Wort, Telaprevir, Telithromycin, Voriconazole, Zotarolimus
PREGNANCY CATEGORY: C
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SKIN
HAIR
NAILS
MUCOSAL
CARDIOVASCULAR
CENTRAL NERVOUS SYSTEM
NEUROMUSCULAR/SKELETAL
GASTROINTESTINAL/HEPATIC
RESPIRATORY
ENDOCRINE/METABOLIC
RENAL
HEMATOLOGIC
OTIC
OCULAR
OTHER
Symbol key
Incidence 
- <1%
- 1-5%
- 5-10%
- 10-15%
- 15-20%
- 20-30%
- >30%
Seriousness
- Hospitalization possible
- Life Threatening
- Fatal
Warnings in other populations
- Breast feeding
- Geriatric
- Pediatric