Rofecoxib
- TRADE NAME: Vioxx (Merck)
- INDICATIONS: Osteoarthritis, acute pain
- CLASS: COX-2 inhibitor, Non-steroidal anti-inflammatory (NSAID)
- HALF-LIFE: 17 hours
CLINICALLY IMPORTANT, POTENTIALLY HAZARDOUS INTERACTIONS WITH:
Anisindione, Anticoagulants, Dicumarol, Lithium, Methotrexate, Tizanidine, Warfarin
PREGNANCY CATEGORY: C
NSAIDs may cause an increased risk of serious cardiovascular and gastrointestinal adverse events, which can be fatal. This risk may increase with duration of use.
This drug has been withdrawn.
CARDIOVASCULAR AND GASTROINTESTINAL RISKS
See full prescribing information for complete boxed warning.
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SKIN.
HAIR.
NAILS.
MUCOSAL.
CARDIOVASCULAR.
CENTRAL NERVOUS SYSTEM.
ENDOCRINE/METABOLIC.
GASTROINTESTINAL/HEPATIC.
HEMATOLOGIC.
NEUROMUSCULAR/SKELETAL.
OCULAR.
RENAL.
RESPIRATORY.
OTHER.
Page last updated 10/23/2023
Symbol key
Incidence
- <1%
- 1-5%
- 5-10%
- 10-15%
- 15-20%
- 20-30%
- >30%
Warnings in other populations
- Breast feeding
- Geriatric
- Pediatric