Propoxyphene
- TRADE NAMES: Algafan; Antalvic; Darvocet-N (Xanodyne); Darvon (Xanodyne); Darvon Compound (Xanodyne); Develin; Dolotard; Doloxene; Liberan; Parvon
- INDICATIONS: Pain
- CLASS: Opiate agonist
- HALF-LIFE: 8–24 hours
CLINICALLY IMPORTANT, POTENTIALLY HAZARDOUS INTERACTIONS WITH:
Alcohol, Alprazolam, Amitriptyline, Carbamazepine, Insulin Aspart, Insulin Degludec, Insulin Glargine, Insulin Glulisine, Linezolid, Lisdexamfetamine, Metoprolol, Phenelzine, Ritonavir, Safinamide, Selegiline, Warfarin
PREGNANCY CATEGORY: C
category D with prolonged use
Darvocet is propoxyphene and acetaminophen; Darvon Compound is propoxyphene and aspirin.
This drug has been withdrawn from the European market. Xanodyne has voluntarily removed its products from the US market. The FDA is advising healthcare professionals to stop prescribing propoxyphene to their patients.
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SKIN.
MUCOSAL.
CARDIOVASCULAR.
CENTRAL NERVOUS SYSTEM.
GASTROINTESTINAL/HEPATIC.
LOCAL.
NEUROMUSCULAR/SKELETAL.
OCULAR.
OTHER.
Page last updated 07/31/2023
Symbol key
Incidence
- <1%
- 1-5%
- 5-10%
- 10-15%
- 15-20%
- 20-30%
- >30%
Warnings in other populations
- Breast feeding
- Geriatric
- Pediatric