Primidone

  • TRADE NAMES: Midone; Mylepsin; Mysoline (Xcel); PMS Primidone; Prysoline; Sertan
  • INDICATIONS: Seizures
  • CLASS: Anticonvulsant, Barbiturate
  • HALF-LIFE: 10–12 hours

Aromatic antiepileptic drugs, phenytoin, phenobarbital, carbamazepine and primidone, are a frequent cause of severe cutaneous adverse reactions. A strong genetic association between HLA-B*1502 and primidone-induced Stevens-Johnson syndrome and toxic epidermal necrolysis has been shown in Han Chinese patients.

Our database has 17 adverse reactions for this drug across the following areas

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SKIN
MUCOSAL
ENDOCRINE/METABOLIC
GENITOURINARY
NEUROMUSCULAR/SKELETAL
OTHER


Page last updated 09/19/2018

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Incidence info

  • <1%
  • 1-5%
  • 5-10%
  • 10-15%
  • 15-20%
  • 20-30%
  • >30%

Seriousness info

  • Hospitalization possible
  • Life threatening
  • Fatal

Warnings in other populations info

  • Breast feeding
  • Geriatric
  • Pediatric